David G. Haegert
It is uncertain as to whether similar or different mechanisms contribute to different subtypes of multiple sclerosis
(MS). A unifying concept proposes that patients with both relapsing-remitting MS (RRMS) and primary progressive
MS (PPMS) have premature thymic involution, which alters peripheral T-cell homeostasis and leads to T-cell
alterations that contribute to the pathogenesis of both MS subtypes.