Andrew Spencer*
In this review, we'll look at how the autonomic nervous system affects dementia patients' Cerebral Blood Flow (CBF). As the world's population ages, the 55 million people who already have dementia will grow in number. Understanding the alterations in vascular physiology associated with dementia may open the door to cutting-edge therapeutic strategies. Numerous dementia subtypes have been shown to have decreased CBF as well as increased cerebrovascular resistance and decreased vasoreactivity. Despite declines in global and regional CBF, Cerebral Autoregulation (CA), a crucial mechanism for maintaining cerebral perfusion, is mostly unaffected by cognitive impairments. Dementia results in a loss of Neurovascular Coupling (NVC), which may be a major cause of cognitive dysfunction. Despite a large number of research examining CBF regulation issues in dementia, less is known about the precise mechanisms causing the reported abnormalities. Disruption of the autonomic component is just one of several paths and processes that disturbances may be connected to. Using the clinical ramifications and potential for new biomarkers and therapeutic targets, we will examine clinical and animal research that explicitly examined the autonomic component of CBF regulation in dementia.