Sujey Palma Florez, Anna Lagunas, Mònica Mir, Josep Samitier
Nanotechnology is a cutting-edge field that extends different possibilities for the study and treatment of different diseases. In this work the most widespread neurodegenerative disease, Alzheimer disease (AD), has been studied under Blood Brain Barrier (BBB) in vitro model. An alternative animal-free in vitro model has been developed for a low cost, easy to work system that simulate the main drug access to the brain, the BBB, by means an Organ-on-a-chip devices [1]. The permeability of the BBB is the main issue to deal when a drug needs to cross this barrier. Moreover, in many neurodegenerative diseases (NDDs) the BBB permeability is strongly affected by vascular and inflammatory problems derived from the NDD. These changes on permeability has to be included in the BBB on a chip to correctly mimic an affected BBB by a specific NDD.